Toxicology

Casarett & Doull's Toxicology The Basic Science of Poisons, by Curtis Klaassen

By Curtis Klaassen

The main depended on all-in-one review of the biomedical and environmental facets of toxicology--NOW extra whole, up to date, and in complete color
The worlds top and so much authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever ahead of. Now in complete colour, and punctiliously revised, the 8th variation of Casarett & Doulls TOXICOLOGY: the fundamental technological know-how of toxins not just promises a finished evaluate of the fundamental elements of toxicology, it deals the main up to date, revealing, and in-depth examine the systemic responses of poisonous substance to be had anywhere.
Combined with the newest pondering by means of the fields most appropriate students plus reliable assurance of common ideas, modes of motion, and chemical-specific toxicity, this landmark textual content maintains to set the normal for toxicology references.
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretation of the fundamental parts of toxicology featured during the text
- increased tables, illustrations, and different visuals are up-to-date with state of the art criteria that makes this version much more present and relevant
- NEW CHAPTERS contain «Toxic results of energy» and «Toxic results of Nanoparticles»

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Extra info for Casarett & Doull's Toxicology The Basic Science of Poisons, Eighth Edition

Example text

Distinguishing a “toxin” from a “toxicant” is not always easy. ” Thus, although technically incorrect, many physicians and others involved in the diagnosis and treatment of poisonings often use the term “toxin” to refer to any toxic substance, regardless of origin. Toxic agents may also be classified in terms of their physical state (gas, dust, liquid, size, eg, nanotoxicology), their chemical stability or reactivity (explosive, flammable, oxidizer), general chemical structure (aromatic amine, halogenated hydrocarbon, etc), or poisoning potential (extremely toxic, very toxic, slightly toxic, etc).

Repeated exposure is divided into 3 categories: subacute, subchronic, and chronic. Subacute exposure refers to repeated exposure to a chemical for 1 month or less, subchronic for 1 to 3 months, and chronic for more than 3 months, although usually this refers to studies with at least 1 year of repeated dosing. These 3 categories of repeated exposure can be by any route, but most often they occur by the oral route, with the chemical added directly to the diet. In human exposure situations, the frequency and duration of exposure are usually not as clearly defined as in controlled animal studies, but many of the same terms are used to describe general exposure situations.

Knowledge about the toxicological effects of a compound affects consumer products, drugs, manufacturing processes, waste cleanup, regulatory action, civil disputes, and broad policy decisions. The expanding influence of toxicology on societal issues is accompanied by the responsibility to be increasingly sensitive to the ethical, legal, and social implications of toxicological research and testing. The convergence of multiple elements has highlighted the evolving ethical dynamics of toxicology.

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